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General description
TIR domain-containing adapter molecule 1 (UniProt Q8IUC6), also known as MyD88-3, Proline-rich, vinculin and TIR domain-containing protein B, Putative NF-kB-activating protein 502H, TICAM-1, TIR domain containing adaptor inducing interferon-b, TIR domain-containing adapter protein inducing IFN-b, Toll-interleukin-1 receptor domain-containing adapter protein inducing interferon b) is encoded by the TICAM1 gene in human. TCAM-1/TRIF/MyD88-3 is as an adaptor molecule that mediates Toll-like receptor 3 (TLR3)-dependent NF-kB activation and cytokine expression. Upon recognition of double-stranded RNA, TLR3 recruits TRIF, which in turn associates with TNF receptor-associated factor 3 (TRAF3) to activate two Ik-B kinase (IKK)-related kinases, TANK-binding kinase 1 (TBK1) and IKKi. These two kinases phosphorylate interferon regulatory factor 3/7 (IRF3/7), resulting in the induction of type I interferons (IFNs) and expression of IFN-inducible genes. TICAM-1 can also mediate NF-kB activation through receptor-interacting protein 1 (RIP1) and TRAF6. Human enterovirus 68 (EV68) is reported to disable TLR3 pathway signaling by cleaving TRIF in infected cells.
~76 kDa observed
Immunogen
GST-tagged recombinant protein corresponding to human TICAM1.
Application
Anti-TICAM1 Antibody, clone 3D5.1 is an antibody against TICAM1 for use in Western Blotting, Immunohistochemistry, Immunocytochemistry.
Immunohistochemistry Analysis: A 1:1,000 dilution from a representative lot detected TICAM1 in human liver tissue.
Immunocytochemistry Analysis: 20 µg/mL from a representative lot detected TICAM1 in HeLa and A431 cells.
Research Category
Apoptosis & Cancer
Research Sub Category
Apoptosis - Additional
Physical form
Format: Purified
Protein G Purified
Purified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Preparation Note
Stable for 1 year at 2-8°C from date of receipt.
Analysis Note
Evaluated by Western Blotting in Raji cell lysate.
Western Blotting Analysis: 0.5 µg/mL of this antibody detected TICAM1 in 10 µg of Raji cell lysate.
Other Notes
Concentration: Please refer to lot specific datasheet.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
| biological source | mouse |
| Quality Segment | 100 |
| conjugate | unconjugated |
| antibody form | purified immunoglobulin |
| antibody product type | primary antibodies |
| clone | 3D5.1, monoclonal |
| species reactivity | human |
| technique(s) | immunocytochemistry: suitable,immunohistochemistry: suitable,western blot: suitable |
| isotype | IgG2aκ |
| NCBI accession no. | NP_891549 |
| UniProt accession no. | Q8IUC6 |
| shipped in | wet ice |
| target post-translational modification | unmodified |
| Gene Information | human ... TICAM1(148022) |
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