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General description
A non-ATP-competitive, reversible, selective inhibitor of p38α-mediated MK2a (mitogen-activated protein kinase-activated protein kinase 2a) phosphorylation (Kiapp = 330 nM). Does not inhibit p38α-mediated phosphorylation of the the other two known p38 substrates, MBP and ATF-2.
A reversible p-amidophenolic compound that selectively inhibits the phosphorylation of MK2a (mitogen-activated protein kinase-activated protein kinase 2a; Kiapp = 330 nM) by p38α in a non-ATP-competitive manner. Does not block the kinase activity of p38α towards the other two known p38 substrates, MBP and ATF-2.
Biochem/physiol Actions
Cell permeable: no
Kiapp = 330 nM against mitogen-activated protein kinase-activated protein kinase 2a (MK2a)
Primary Target
Mk2α
Product does not compete with ATP.
Reversible: yes
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Davidson, W., et al. 2004. Biochemistry43, 11658.
Lukas, S.M., et al. 2004. Biochemistry43, 9950.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
| Quality Segment | 100 |
| assay | ≥95% (HPLC) |
| form | solid |
| manufacturer/tradename | Calbiochem® |
| storage condition | OK to freeze,protect from light |
| color | pale yellow |
| solubility | DMSO: 5 mg/mL,ethanol: 5 mg/mL |
| shipped in | ambient |
| storage temp. | 2-8°C |
| SMILES string | Fc1c(cccc1)c2ccc(cc2)CCCC(=O)Nc3ccc(cc3)O |
| InChI | 1S/C22H20FNO2/c23-21-6-2-1-5-20(21)17-10-8-16(9-11-17)4-3-7-22(26)24-18-12-14-19(25)15-13-18/h1-2,5-6,8-15,25H,3-4,7H2,(H,24,26) |
| InChI key | ODYAQBDIXCVKAE-UHFFFAOYSA-N |
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