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General description
Kinesin-like protein KIF3A (UniProt Q9Y496; also known as Kinesin family protein 3A, Microtubule plus end-directed kinesin motor 3A) is encoded by the KIF3A (also known as FLA10, KIF3, KLP-20) gene (Gene ID 11127) in human. Kinesin-2 is a heterotrimeric motor protein composed of two kinesin-related subunits, KIF3A and KIF3B, and an associated protein KAP3. The kinesin-2 motor KIF3A/B drives intraflagellar transport (IFT) of tubulins and other axonemal building blocks in cilia and flagella, pigment granules in melanosomes, and vesicles in neurons. Defects in these transport processes are linked to polycystic kidney disease and neurodegenerative diseases.
~75 kDa observed
Immunogen
Epitope: C-terminal
KLH-conjugated linear peptide corresponding to the C-terminal of human KIF3A.
Application
Research Category
Apoptosis & Cancer
Research Sub Category
Apoptosis - Additional
This Anti-KIF3A Antibody, clone 4F9.1 is validated for use in Western Blotting and Immunohistochemistry for the detection of KIF3A.
Western Blotting Analysis: 1.0 µg/mL from a representative lot detected KIF3A in 10 µg of rat hippocampus tissue lysate.
Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected KIF3A in human cerebellum and human cerebral cortex tissue.
Physical form
Format: Purified
Protein G Purified
Purified mouse monoclonal IgG1κ antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Preparation Note
Stable for 1 year at 2-8°C from date of receipt.
Analysis Note
Evaluated by Western Blotting in mouse cerebellum tissue lysate.
Western Blotting Analysis: 1.0 µg/mL of this antibody detected KIF3A in 10 µg of mouse cerebellum tissue lysate.
Other Notes
Concentration: Please refer to lot specific datasheet.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
| biological source | mouse |
| Quality Segment | 100 |
| conjugate | unconjugated |
| antibody form | purified antibody |
| antibody product type | primary antibodies |
| clone | 4F9.1, monoclonal |
| species reactivity | rat, mouse, human |
| technique(s) | immunohistochemistry: suitable,western blot: suitable |
| isotype | IgG1κ |
| NCBI accession no. | NP_001287720 |
| UniProt accession no. | Q9Y496 |
| shipped in | dry ice |
| target post-translational modification | unmodified |
| Gene Information | human ... KIF3A(11127) |
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