首页> 化学试剂> 其他化学试剂> 其他> bpV(phen)，10MG，203695-10MGCN，Sigma

收藏产品

bpV(phen)，10MG，203695-10MGCN，Sigma

销售价： ¥ 2437.85 / 件

在线询价

优惠：请询价

订货号： 0BV4589

品牌型号： Sigma 203695-10MGCN

货期：询货期

最小订货量： 1件

+ -

加入购物车

联系我们

400-920-3909

微信扫一扫，手机采购

精选商品

Istaroxime hydrochloride，5MG，SML3953-5MG，Sigma

销售价： ¥ 1345.68

加入购物车

P¹,P⁵-二(腺苷-5′)五磷酸盐三锂盐，10MG，D6392-10MG，Sigma

销售价： ¥ 1943.06

加入购物车

甘油醛-3-磷酸脱氢酶来源于兔肌肉，1000UNITS，G2267-1KU，Sigma

销售价： ¥ 1036.20

加入购物车

GSK-650394，25MG，SML0773-25MG，Sigma

销售价： ¥ 6033.82

加入购物车

胰蛋白酶抑制剂来源于鸡蛋白，500MG，T9253-500MG，Sigma

销售价： ¥ 1704.73

加入购物车

脱氧核糖核酸来源于小牛胸腺，5MG，D4522-5MG，Sigma

销售价： ¥ 1816.23

加入购物车

商品介绍
规格参数
包装参数

产品介绍 Product Description

General description

A potent insulin receptor kinase (IRK) activator and protein phosphotyrosine phosphatase inhibitor. Excellent insulin mimetic for in vitro and in vivo use (15 µg/kg). Inhibits in situ dephosphorylation of autophosphorylated insulin receptors with greater than 1000-fold potency over sodium orthovanadate. Arrests proliferation of neuroblastoma NB 41 and glioma C6 cells at the G₂/M transition of the cell cycle. Also reported to potently inhibit PTEN (IC₅₀ = 38 nM). The water content varies from lot to lot and is supplied on the label along with the lot-specific molecular weight.
A potent protein phosphotyrosine phosphatase inhibitor and insulin receptor kinase (IRK) activator. Excellent insulin mimetic at 15 µg/kg in vitro and in vivo for use. Inhibits the in situ dephosphorylation of autophosphorylated insulin receptors with over 1000-fold greater potency than sodium orthovanadate. Arrests proliferation of neuroblastoma NB 41 and glioma C6 cells at the G₂/M transition of the cell cycle. Also reported to potently inhibit PTEN (IC₅₀ = 38 nM).
The water content varies from lot to lot and is supplied on the label along with the lot-specific molecular weight.

Biochem/physiol Actions

Cell permeable: no
Primary Target
PTEN
Product does not compete with ATP.
Reversible: no

Packaging

Packaged under inert gas

Preparation Note

Unstable in solution; reconstitute just prior to use.

Other Notes

Schmid, A.C., et al. 2004. FEBS Lett.566, 35.
Muzyamba, M.C., et al. 1999. J. Physiol. 517, 421.
Drake, P.G., et al. 1996. Endocrinology137, 4960.
Bevan, A.P., et al. 1995. Am. J. Physiol.268, E60.
Bevan, A.P., et al. 1995. J. Biol. Chem. 270, 10784.
Yale, J.F., et al. 1995. Diabetes 44, 1274.
Posner, B.I., et al. 1994. J. Biol. Chem. 269, 4596.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

技术参数 Specifications

Quality Level	100
assay	≥99% (⁵¹V-NMR)
form	solid
potency	38 nM IC₅₀
manufacturer/tradename	Calbiochem^®
storage condition	OK to freeze,protect from light
color	yellow
solubility	water: 5 mg/mL
shipped in	ambient
storage temp.	−20°C
SMILES string	[V]=O.[K+].n1c2c3ncccc3ccc2ccc1.OO.OO
InChI	1S/C12H8N2.K.2H2O2.O.V/c1-3-9-5-6-10-4-2-8-14-12(10)11(9)13-7-1;;21-2;;/h1-8H;;21-2H;;/q;+1;;;;
InChI key	MQPXOTNOFVCXDA-UHFFFAOYSA-N

长度(mm)
宽度(mm)
高度(mm)
重量(kg)