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- 规格参数
- 包装参数
General description
Nuclear receptor subfamily 1 group I member 2 (UniProt O75469; also known as Orphan nuclear receptor PAR1, Orphan nuclear receptor PXR, Pregnane X nuclear receptor, Steroid and xenobiotic receptor, SXR) is encoded by the NR1I2 (also known as BXR, PAR, PRR, PXR, SAR, SXR, ONR1) gene (Gene ID 8856) in human. Pregnane X receptor (PXR) is a nuclear receptor that displays similarity to PPAR and RXR. PXR is activated by a large number of endogenous and exogenous chemicals including steroids and antibiotics. One of the key roles of PXR is the induction of CYP3A4, a P450 enzyme involved in drug metabolism.
~53 kDa observed. Uniprot describes 7 isoforms produced by alternative splicing ranging from ~40 kDa-54 kDa
Immunogen
KLH-conjugated linear peptide corresponding to human PXR.
Application
Detect PXR using this Anti-PXR Antibody, clone 1F10.1 validated for use in Western Blotting.
Western Blotting Analysis: 1.0 µg/mL from a representative lot detected PXR in 10 µg of human liver tissue lysate.
Biochem/physiol Actions
Epitope is present in all 7 alternative spliced isoforms (isoform 1A/PRR1-A, 1B/PRR1-B, 1C/PRR1-C, 2A/PRR2-A, 2B/PRR2-V, 2C/PRR2-C, and isoform 3).
Physical form
Format: Purified
Analysis Note
Evaluated by Western Blotting in human colon tissue lysate.
Western Blotting Analysis: 1.0 µg/mL of this antibody detected PXR in 10 µg of human colon tissue lysate.
Other Notes
Concentration: Please refer to lot specific datasheet.
| biological source | mouse |
| Quality Level | 100 |
| conjugate | unconjugated |
| antibody form | purified immunoglobulin |
| antibody product type | primary antibodies |
| clone | 1F10.1, monoclonal |
| species reactivity | human |
| species reactivity (predicted by homology) | chimpanzee (based on 100% sequence homology), gorilla (based on 100% sequence homology) |
| technique(s) | western blot: suitable |
| isotype | IgG2bκ |
| NCBI accession no. | NP_003880 |
| UniProt accession no. | O75469 |
| shipped in | dry ice |
| target post-translational modification | unmodified |
| Gene Information | human ... NR1I2(8856) |
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