17β-雌二醇,1G,3301-1GMCN,Sigma

销售价: ¥ 830.53 / 件
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订货号 0BV4564
品牌型号 Sigma 3301-1GMCN
货期 询货期
最小订货量 1件
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产品介绍 Product Description

General description

17β-Estradiol is a potent estrogen, a steroid hormone, involved in reproductive and endocrine functions in mammals. It binds to estrogen receptors (ERα and ERβ) to regulate gene expression, influencing reproductive functions such as the proliferation of the uterine endometrium, ovulation, and maintenance of pregnancy. Additionally, 17β-Estradiol is involved in modulating metabolic processes, including lipid metabolism and insulin sensitivity, and exerts neuroprotective effects in the central nervous system.


Application

17β-Estradiol has been used to treat primary rat cortical neurons, to investigate its effects on neuronal responses to interleukin (IL)-6 and soluble IL-6 receptor treatment. It has also been administered subcutaneously to ovariectomized female mice to investigate its effects on Crhr1 and Esr1 mRNA expression in the nucleus accumbens.


Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany


Disclaimer

毒性:有害 & 致癌/致畸性(E)


技术参数 Specifications
Quality Level100
descriptionRTECS - KG2975000
Merck USA index - 14, 3703
assay≥97% (by assay)
formsolid
manufacturer/tradenameCalbiochem®
storage conditionOK to freeze
color white to off-white
solubilityethanol: 5 mg/mL
shipped inambient
storage temp.2-8°C
SMILES stringO[C@@H]1[C@@]2([C@H]([C@H]3[C@H](CC2)c4c(cc(cc4)O)CC3)CC1)C
InChI1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17+,18+/m1/s1
InChI keyVOXZDWNPVJITMN-ZBRFXRBCSA-N
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