Anti-COMP (Thrombospondin-5) Antibody, clone 484D1，100UG，MABT36，Sigma 供应商、价格、厂家、报价、规格参数

产品介绍 Product Description

General description

Cartilage oligomeric matrix protein (COMP, Thrombospondin-5, TSP5) is a member of the thrombospondin gene family. COMP is usually found in the extracellular matrix and is regularly linked to cartilage tissue. COMP seems to protect chondrocytes against cell death, whether tumor necrosis factor alpha is present or not. Defects in COMP are the cause of multiple epiphyseal dysplasia type 1 and pseudoachondroplasia.
~83 kDa Observed

Immunogen

Human cartilage oligometric matrix recombinant protein.

Application

Immunohistochemistry (Frozen Tissue) Analysis: A previous lot of this antibody was shown to detect COMP in osteoblasts lining the bone spicules of adult human subchondral bone section (Di Cesare, P.E., et al. (2000). Journal of Orthopaedic Research. 18:713.720).
Research Category
Cell Structure
Research Sub Category
ECM Proteins
This Anti-COMP (Thrombospondin-5) Antibody, clone 484D1 is validated for use in WB, IH for the detection of COMP (Thrombospondin-5).

Physical form

Format: Purified
Protein G Purified
Purified rat monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Preparation Note

Stable for 1 year at 2-8°C from date of receipt.

Analysis Note

Control
Human chrondrocyte cell lysate
Evaluated by Western Blot in human chrondrocytes cell lysate.

Western Blot Analysis: 0.5 µg/mL of this antibody detected COMP in 10 µg of human chrondrocyte cell lysate.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

技术参数 Specifications

biological source	rat
Quality Segment	100
conjugate	unconjugated
antibody form	purified immunoglobulin
antibody product type	primary antibodies
clone	484D1, monoclonal
species reactivity	human
technique(s)	immunohistochemistry: suitable,western blot: suitable
isotype	IgG1κ
NCBI accession no.	NP_000086
UniProt accession no.	P49747
shipped in	wet ice
target post-translational modification	unmodified
Gene Information	human ... COMP(1311)

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