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General description
LARS is the critical cytoplasmic enzyme that charges the tRNA for leucine to become L-leucyl-tRNA, or tRNA(Leu). LARS is thus critical for protein biosynthesis and LARS is up regulated, like many proteins, in cancer. LARS is localized in the cytoplasm and regulated via acetylation. Interestingly, recent research demonstrates that LARS and other tRNA synthetases play key roles as amino acid cellular sensors in my cellular signaling pathways such as mTOR which regulate cell size, protein translation, and even autophagy.
~140 kDa observed
Immunogen
KLH-conjugated linear peptide corresponding to human LARS near the C-terminus.
Application
This Anti-LARS Antibody is validated for use in Western Blotting and Immunohistochemistry (Paraffin) for the detection of LARS.
Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected LARS in human kidney and human liver tissue.
Analysis Note
Evaluated by Western Blotting in HUVEC cell lysate.
Western Blotting Analysis: 0.2 µg/mL of this antibody detected LARS in 10 µg of HUVEC cell lysate.
Other Notes
Concentration: Please refer to lot specific datasheet.
| biological source | rabbit |
| Quality Segment | 100 |
| conjugate | unconjugated |
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone | polyclonal |
| purified by | affinity chromatography |
| species reactivity | human |
| technique(s) | immunohistochemistry: suitable (paraffin),western blot: suitable |
| NCBI accession no. | NP_064502 |
| UniProt accession no. | Q9P2J5 |
| shipped in | wet ice |
| target post-translational modification | unmodified |
| Gene Information | human ... LARS(51520) |
| 长度(mm) | |
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