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General description
Ras-related protein Rab-8A (RAB8A) is one of two Rab8 isoforms, which belong to the superfamily of GTPases. They cycle between an active GTP-bound state, formed from interaction with guanine nucleotide exchange factors (GEFs) such as Rabin8 and GRAB; and an inactive GDP-bound state via interaction with GTPase activating proteins (GAPs) such as TBC1D1. Rab8A activates various effector molecules, which are coupled to intracellular signaling networks that mediate membrane and vesicular trafficking, and actin remodeling. Rab8A is found in the golgi network, perinuclear region, plasma membrane, lamellipodia, and cilia, among other regions.
~24 kDa observed. Uncharacterized bands may be observed at ~110 kDa and ~38 kDa
Immunogen
Epitope: C-terminus
KLH-conjugated linear peptide corresponding to the C-terminus of human RAB8A.
Application
Research Category
Cell Structure
Research Sub Category
Vesicular Trafficking
This Anti-RAB8A Antibody is validated for use in Western Blotting for the detection of RAB8A.
Western Blot Analysis: A representative lot from an independent laboratory detected RAB8A in human cerebellum and brain.
Biochem/physiol Actions
This antibody recognizes the C-terminus of RAB8A.
Physical form
Affinity purified
Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Preparation Note
Stable for 1 year at 2-8°C from date of receipt.
Analysis Note
Control
Serum starved HeLa cell lysate
Evaluated by Western Blot in serum starved HeLa cell lysate.
Western Blot Analysis: 1 µg/mL of this antibody detected RAB8A in serum starved HeLa cell lysate.
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
| biological source | rabbit |
| Quality Segment | 100 |
| conjugate | unconjugated |
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone | polyclonal |
| purified by | affinity chromatography |
| species reactivity | human |
| species reactivity (predicted by homology) | mouse (based on 100% sequence homology), bovine (based on 100% sequence homology) |
| technique(s) | western blot: suitable |
| NCBI accession no. | NP_005361 |
| UniProt accession no. | P61006 |
| shipped in | wet ice |
| target post-translational modification | unmodified |
| Gene Information | human ... RAB8A(4218) mouse ... Rab8A(17274) |
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