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General description
The Arrestin family consists of four members: Arrestin 1 (visual Arrestin), Arrestin 2 (beta Arrestin 1), Arrestin 3 (beta Arrestin 2), and Arrestin 4 (cone Arrestin). While visual and cone Arrestins are found almost exclusively in the retina, beta Arrestins 1 and 2 are ubiquitously expressed. Beta Arrestins appear to act as negative regulators on G protein-coupled receptors, (Lefkowitz, 1998). Interaction with molecules such as clathrin, AP-2 and NSF directs the clathrin-mediated internalization of G-protein-coupled receptors. Interaction with molecules such as Src, Raf, Erk, ASK1 and JNK3 appears to regulate several pathways that result in the activation of MAP kinases, (Lin, 1998; Miller, 2001).
~47 kDa
Immunogen
Epitope: a.a. 357-372
KLH conjugated synthetic peptide corresponding to amino acids 357-372 of human beta arrestin 1.
Application
Anti-beta Arrestin 1 Antibody, clone 3H11.2 detects level of beta Arrestin 1 & has been published & validated for use in WB & IF.
Research Category
Cell Structure
Research Sub Category
Sensory & PNS
G-proteins
Biochem/physiol Actions
Other species have not been tested.
Reacts with human beta-arrestin 1.
Physical form
Format: Purified
Purified in PBS with 0.05% NaN3.
Preparation Note
Maintain at 2-8°C in undiluted aliquots for up to 1 year after date of receipt.
Analysis Note
Control
HEK293 cell lysate
Evaluated on a representative lot by Western blot in HEK293 cell lysate.
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
| biological source | mouse |
| Quality Level | 100 |
| conjugate | unconjugated |
| antibody form | saturated ammonium sulfate (SAS) precipitated |
| antibody product type | primary antibodies |
| clone | 3H11.2, monoclonal |
| species reactivity | human |
| technique(s) | immunofluorescence: suitable,western blot: suitable |
| isotype | IgMκ |
| NCBI accession no. | NP_004032.2 |
| UniProt accession no. | P49407 |
| shipped in | wet ice |
| target post-translational modification | unmodified |
| Gene Information | human ... ARRB1(408) |
| 长度(mm) | |
| 宽度(mm) | |
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| 重量(kg) |
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