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- 规格参数
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General description
A cell-permeable bis-arylidene cyclohexanone compound that acts as a p300/CBP-selective histone acetyltransferase inhibitor (IC50 = 5 µM), while it affects GCN5 and PCAF only at much higher concentrations (30% and 0% inhibition, respectively, at 5 µM inhibitor concentration). Shown to decrease histone H3 acetylation (IC50 ≤ 40 µM) and induce chromatin condensation in HeLa cells.
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month.
Other Notes
Costi, R., et al. 2007. J. Med. Chem.50, 1973.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
| Quality Level | 100 |
| assay | ≥97% (HPLC) |
| form | solid |
| manufacturer/tradename | Calbiochem® |
| storage condition | OK to freeze,protect from light |
| color | yellow |
| solubility | ethanol: 10 mg/mL,DMSO: 25 mg/mL |
| shipped in | ambient |
| storage temp. | 2-8°C |
| SMILES string | Brc1c(ccc(c1)\C=C2/CCC\C(=C/c3cc(c(cc3)O)Br)\C/2=O)O |
| InChI | 1S/C20H16Br2O3/c21-16-10-12(4-6-18(16)23)8-14-2-1-3-15(20(14)25)9-13-5-7-19(24)17(22)11-13/h4-11,23-24H,1-3H2/b14-8+,15-9+ |
| InChI key | YOLKEKNTCBWPSD-VOMDNODZSA-N |
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¥ 2707.32
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¥ 4039.86
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¥ 1724.25
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¥ 4968.78
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瓶顶过滤器-500ml容量,MF75TM系列，聚苯乙烯外壳，75mmPES滤膜，孔径0.45um,适合瓶颈尺寸33mm，12/箱，295-3345，Nalgene，Thermofisher，赛默飞世尔¥ 1938.54
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¥ 1476.00
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¥ 4020.77
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