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- 规格参数
- 包装参数
General description
A diphenylsulfone-sulfonamide compound that counteracts the antagonizing effect of SARP-2/sFRP-1 (secreted frizzled related protein-1) against Wnt-3/frizzled interaction and Wnt-3/frizzled-stimulated cellular functions (EC50 = 1.27 µM in a U2OS-based reporter assay) with a reported aqueous solubility of 26 µg/ml at pH 7.4 and in vitro half-lives of 12 and 26.7 min using rat and human microsomes, respectively.
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Other Notes
Gopalsamy, A., et al. 2008. J. Med. Chem.51, 7670.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
| Quality Segment | 100 |
| assay | ≥95% (HPLC) |
| form | oil |
| manufacturer/tradename | Calbiochem® |
| storage condition | OK to freeze,protect from light |
| color | clear |
| solubility | DMSO: 5 mg/mL |
| shipped in | ambient |
| storage temp. | 2-8°C |
| SMILES string | [S](=O)(=O)(NCCCN(C)C)c1c(ccc(c1)[S](=O)(=O)c2ccccc2)CC |
| InChI | 1S/C19H26N2O4S2/c1-4-16-11-12-18(26(22,23)17-9-6-5-7-10-17)15-19(16)27(24,25)20-13-8-14-21(2)3/h5-7,9-12,15,20H,4,8,13-14H2,1-3H3 |
| InChI key | BHFFSIFXFHJJNJ-UHFFFAOYSA-N |
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¥ 2707.32
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¥ 1563.36
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¥ 1451.54
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¥ 2151.46
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