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General description
26 kDa Calculated
Bcl-2 suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Bcl-2 also regulates cell death by controlling the mitochondrial membrane permeability and appears to function in a feedback loop system with caspases. It appears to Inhibit caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). Further understanding in how Bcl-2 functions and interacts with other proteins to promote or inhibit apoptosis may lead to new treatments for cancer, neurological disorders and autoimmune diseases.
Immunogen
KLH-conjugated, synthetic peptide corresponding to human Bcl-2
Application
Research Category
Apoptosis & Cancer
Research Sub Category
BCL2 & Inhibition
This Milli-Mark Bcl-2 antibody is validated for use in Flow for the detection of the Milli-Mark Bcl-2 protein.
Biochem/physiol Actions
Antibody recognizes Bcl-2.
Physical form
Protein G Purified
Purified mouse monoclonal IgG2a conjugated to Alexa Fluor™ 488 in PBS with 0.1% sodium azide and 15 mg/mL BSA.
Preparation Note
Maintain refrigerated at 2-8 °C protected from light in undiluted aliquots for up to 6 months from date of receipt.
Analysis Note
Control
Jurkat Cells
Evaulated by flow cytometery using Jurkat cells.
Legal Information
ALEXA FLUOR is a trademark of Life Technologies
MILLI-MARK is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Alexa Fluor™ is a registered trademark of Molecular Probes, Inc.
| biological source | mouse |
| Quality Segment | 100 |
| conjugate | ALEXA FLUOR™ 488 |
| antibody form | purified immunoglobulin |
| antibody product type | primary antibodies |
| clone | AW604, monoclonal |
| species reactivity | human |
| manufacturer/tradename | Milli-Mark® |
| technique(s) | flow cytometry: suitable |
| isotype | IgG2a |
| NCBI accession no. | NP_000624 |
| UniProt accession no. | P10415 |
| shipped in | wet ice |
| target post-translational modification | unmodified |
| Gene Information | human ... BCL2(596) |
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¥ 4039.86
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¥ 1724.25
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¥ 1956.41
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¥ 8520.40
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¥ 4390.38
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¥ 1783.21
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¥ 2452.91
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¥ 3896.11
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¥ 3476.87
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