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General description
A cell-permeable isoxazole compound that selectively induces robust neuronal differentiation (Effective concentration = 20 µM) in various stem/progenitor cells. Induces insulin expression, and activates ERK signaling and histone acetylation in MIN6 pancreatic β cells. The underlying excitation-neurogenesis signaling is comprised of, at least in part, an initial NMDA receptor- and L-type chanenels-mediated Ca2+ influx, followed by an activation of CaMKII, phosphorylation/nuclear export of the MEF2 repressor HDAC5, the subsequent de-repression of MEF2, and the eventual activation of the HDAC-MEF2 epigenetic/transcriptional regulatory network.
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Dioum, E.M., et al. 2011. Proc. Natl. Acad. Sci. USA108, 20713.
Zhang, L., et al. 2011. Differentiation81, 233.
Sadek, H., et al. 2008. Proc. Natl. Acad. Sci. USA105, 6063.
Schneider, J.W., et al. 2008. Nat. Chem. Biol.4, 408.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
| Quality Segment | 100 |
| assay | ≥95% (HPLC) |
| form | solid |
| manufacturer/tradename | Calbiochem® |
| storage condition | OK to freeze,protect from light |
| color | off-white |
| solubility | ethanol: 3 mg/mL,DMSO: 5 mg/mL |
| shipped in | ambient |
| storage temp. | 2-8°C |
| SMILES string | [s]1c(ccc1)c2[o]nc(c2)C(=O)NC3CC3 |
| InChI | 1S/C11H10N2O2S/c14-11(12-7-3-4-7)8-6-9(15-13-8)10-2-1-5-16-10/h1-2,5-7H,3-4H2,(H,12,14) |
| InChI key | SYENTKHGMVKGAQ-UHFFFAOYSA-N |
| 长度(mm) | |
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| 重量(kg) |
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NNALGENE 180透明塑料管，透明，柔软，多用，经济，内径 x 外径x壁厚，1/4 x 1/2 x 1/8，英寸，每箱数量50，50/箱，8000-0080，Thermofisher，赛默飞世尔
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