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Biochem/physiol Actions
Potent and selective CDK9-cyclin T1 complex degrader with stronger inhibition than THAL-SNS-032 against oncogenic transcription driven by Myc and AR.
LL-K9-3 is a potent and selective CDK9-cyclin T1 complex degrader (CDK9/CycT1 DC50 = 662/589 nM post 24h treatment, 22RV1 cells) with little potency toward other CDKs (1, 2, 4-7) or cyclins (E1, H, T2). LL-K9-3 exhibits higher antiproliferation activity than SNS-032 against 22RV1 prostate carcinoma cell (IC50 = 95 vs. 384 nM post 5-day treatment). Comparing to SNS-032 and THAL-SNS-032, LL-K9-3 shows stronger inhibition against oncogenic transcription driven by Myc and AR, as well as on several AR intrinsic target genes.
| Quality Segment | 100 |
| assay | ≥98% (HPLC) |
| form | powder |
| color | white to beige |
| solubility | DMSO: 2 mg/mL, clear |
| storage temp. | -10 to -25°C |
| SMILES string | O=S(CCNC(CO[C@H]1[C@H](C(C)C)CC[C@@H](C)C1)=O)(N2CCC(C(NC3=NC=C(S3)SCC4=NC=C(O4)C(C)(C)C)=O)CC2)=O |
| InChI | 1S/C31H49N5O6S3/c1-20(2)23-8-7-21(3)15-24(23)41-18-26(37)32-11-14-45(39,40)36-12-9-22(10-13-36)29(38)35-30-34-17-28(44-30)43-19-27-33-16-25(42-27)31(4,5)6/h16-17,20-24H,7-15,18-19H2,1-6H3,(H,32,37)(H,34,35,38)/t21-,23+,24-/m1/s1 |
| InChI key | NPRIWHDFWDSJRZ-YFNKSVMNSA-N |
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