SRT2104，25MG，SML3754-25MG，Sigma

Biochem/physiol Actions

Orally active sirtuin 1 (Sirt1) activator in vitro and in vivo.
SRT2104 is an orally active, potent and highly selective activator of the NAD+-dependent deacetylase sirtuin Sirt1 (EC1.5 = 450 nM) with in vivo efficacy in various animal models, including age-related bone/muscle loss (100 mg/kg/d via chow to mice), HD (0.5% in chow to mice), TNF-induced optic nerve degeneration (2-200 pmol via intravitreal injection to rats).