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- 规格参数
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Biochem/physiol Actions
Cell penetrant and potent inhibitor of human enterovirus 71 (EV71) translation and replication that targets the IRES domain of EV71
DMA-135 is a cell penetrant and potent inhibitor of human enterovirus 71 (EV71) translation and replication that targets the IRES domain of EV71. DMA-135 binds allosterically to EV71 SLII RNA and stabilizes ternary complex consisting of AUF1-SLII-DMA-135. Also, previous data indicate that DMA-135 exhibit comparable affinity to HIV-1-TAR and HIV-2-TAR.
| Quality Segment | 100 |
| assay | ≥98% (HPLC) |
| form | powder |
| storage condition | desiccated |
| color | white to beige |
| solubility | H2O: 2 mg/mL, clear |
| storage temp. | 2-8°C |
| SMILES string | CN(C1=C(N=C(C(N)=N1)C(NC(N)=N)=O)C#CC2=CC=CC=C2)C.[xHCl] |
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