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Biochem/physiol Actions
Cyclopentenyl uracil is a non-cytotoxic inhibitor of uridine kinase that act as a potent inhibitor of pyrimidine salvage in the intact mouse. Combination of Cyclopentenyl uracil with GSK983 significantly reduces viral infection of dengue serotype 2 (DENV-2) strain 16681 in cultures of the A549 lung carcinoma cell line. Cyclopentenyl uracil in combination with GSK983 enhances therapeutic index of viral RdRp inhibitor R1479.
non-cytotoxic inhibitor of uridine kinase that act as a potent inhibitor of pyrimidine salvage
| Quality Segment | 100 |
| assay | ≥98% (HPLC) |
| form | powder |
| color | white to beige |
| solubility | DMSO: 2 mg/mL, clear |
| storage temp. | 2-8°C |
| SMILES string | [nH]1[c]([n](cc[c]1=O)[C@H]2[C@@H]([C@@H](C(=C2)CO)O)O)=O |
| InChI | 1S/C10H12N2O5/c13-4-5-3-6(9(16)8(5)15)12-2-1-7(14)11-10(12)17/h1-3,6,8-9,13,15-16H,4H2,(H,11,14,17)/t6-,8-,9+/m1/s1 |
| InChI key | FCWVOJUKQSHZIV-VDAHYXPESA-N |
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¥ 1683.78
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¥ 8293.41
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¥ 8520.40
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¥ 8135.09
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¥ 2617.87
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¥ 4020.77
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