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- 规格参数
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Application
Telbivudine has been used to explore the mechanisms of telbivudine (LdT) induced creatine kinase (CK) elevation.
Biochem/physiol Actions
Telbivudine is a nucleoside analog that is widely used to treat hepatitis B virus (HBV) infection.
Telbivudine is a synthetic molecule containing β-L-configuration. Telbivudine improves the estimated glomerular filtration rate (eGFR) in response to chronic hepatitis B (CHB). It prevents perinatal transmission and enhances the hepatitis B e antigen (HBeAg) seroconversion. It is also known to cause side effects such as creatine kinase (CK) elevation and fatal rhabdomyolysis.
Telbivudineis a Hepatitis B antiviral agent.
| Quality Segment | 100 |
| assay | ≥98% (HPLC) |
| form | powder |
| optical activity | [α]/D -15 to -22°, c = 1 in H2O |
| color | white to beige |
| solubility | H2O: 10 mg/mL (clear solution) |
| storage temp. | 2-8°C |
| SMILES string | CC1=CN([C@@H]2C[C@@H](O)[C@H](CO)O2)C(=O)NC1=O |
| InChI | 1S/C10H14N2O5/c1-5-3-12(10(16)11-9(5)15)8-2-6(14)7(4-13)17-8/h3,6-8,13-14H,2,4H2,1H3,(H,11,15,16)/t6-,7+,8+/m1/s1 |
| InChI key | IQFYYKKMVGJFEH-CSMHCCOUSA-N |
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