- 商品介绍
- 规格参数
- 包装参数
Application
TRAIL human has been used in immunofluorescence analyses, to study the delocalization of melanoma antigen-D2 in the nucleoplasm after a cellular stress.
Human TRAIL can be used as a selection agent for treating human cells for phenotypic enrichments. The product can also be used in chemical transfection for identifying Small RNA Modulators of TRAIL-Induced Apoptosis Pathway by utilizing libraries of synthetic small interfering RNA (siRNA) and microRNAs (miRNA).
Biochem/physiol Actions
TRAIL is a cytokine with anti-inflammatory, and antitumor activity. It is expressed in various cells including immune cells, vascular cells and adipocytes. TRAIL is associated with vascular endothelial cell protection.
TNF-related apoptosis-inducing ligand (TRAIL) is a type II transmembrane protein that belongs to TNF family. The product present in both soluble as well as membrane-bound form, can induce rapid apoptosis of various transformed cell lines but not the normal cells. Additionally, the product can also induce apoptotic cell death in TRAIL-sensitive U343MG cells.
Type II transmembrane protein of the TNF superfamily. Ligand for apoptosis-inducing death receptors DR4 and DR5, decoy receptors DcR1 and DcR2, and osteoprotegerin. Approximately 28% amino acid sequence identity to FAS ligand. Human and mouse TRAIL share 65% sequence identity.
Physical form
Lyophilized from phosphate buffered saline
Analysis Note
The biological activity is determined by its ability to induce apoptotic cell death in TRAIL-sensitive LN-18 cells.
| biological source | human |
| Quality Segment | 200 |
| recombinant | expressed in E. coli |
| description | extracellular domain |
| assay | ≥98% (SDS-PAGE and HPLC) |
| form | lyophilized powder |
| mol wt | 19.6 kDa,predicted mol wt ~21 kDa |
| technique(s) | immunofluorescence: suitable |
| impurities | endotoxin, tested |
| UniProt accession no. | P50591 |
| storage temp. | −20°C |
| Gene Information | human ... TNFSF10(8743) |
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¥ 2622.09
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¥ 2290.21
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¥ 1683.78
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¥ 9737.84
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¥ 4390.38
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¥ 10277.12
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¥ 2882.02
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NALGENE 180透明塑料管，透明，柔软，多用，经济，内径 x 外径x壁厚，1/8 x 1/4 x 1/16，英寸，每箱数量50，50/箱，8000-0020，Thermofisher，赛默飞世尔
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