- 商品介绍
- 规格参数
- 包装参数
General description
LATS2 is a serine/threonine protein kinase belonging to the LATS tumor suppressor family. The kinase activity and two conserved domains within LATS2 are responsible for the suppression of tumorigenicity and inhibition of cell growth. LATS2 negatively regulates the cell cycle by controlling G1/S and/or G2/M transition. LATS2 interacts with the centrosomal proteins AURORA A and Ajuba and is required for accumulation of γ-tubulin and spindle formation at the onset of mitosis. LATS2 also interacts with a negative regulator of p53 and may function in a positive feedback loop with p53 that responds to cytoskeleton damage. LATS2 can also function as a co-repressor of androgen-responsive gene expression.
Physical form
Supplied in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Preparation Note
after opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles
| recombinant | expressed in baculovirus infected Sf9 cells |
| assay | ≥70% (SDS-PAGE) |
| form | buffered aqueous glycerol solution |
| mol wt | ~98 kDa |
| NCBI accession no. | NM_014572 |
| shipped in | dry ice |
| storage temp. | −70°C |
| Gene Information | human ... LATS2(26524) |
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¥ 4164.19
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¥ 2622.09
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¥ 1563.36
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¥ 2013.69
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¥ 1302.89
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¥ 3109.49
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¥ 5167.58
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