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Biochem/physiol Actions
Proliferating cell nuclear antigen-l1 (PCNA) is a member of the scaffold B class. It acts as a linker at the monomer-monomer interface. PCNA-I1 has the ability to block the development of primary cultures of bone marrow mesenchymal stem cells, endothelial cells, lymphocytes, mammary epithelial cells and prostate epithelial cells.
PCNA-I1 is a PCNA inhibitor.
PCNA-I1 is a small molecule PCNA inhibitor that selectively binds to PCNA trimers and reduces the association of PCNA with chromatin. PCNA-I1 induces S and G2/M phase cell cycle arrest in tumor cells with greater efficacy than non-transformed cells.
| Quality Segment | 100 |
| assay | ≥98% (HPLC) |
| form | powder |
| color | white to beige |
| solubility | DMSO: 10 mg/mL, clear |
| storage temp. | 2-8°C |
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¥ 1596.77
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¥ 2013.69
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¥ 1302.89
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¥ 1956.41
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¥ 3152.47
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¥ 4897.21
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¥ 20380.83
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¥ 2151.46
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¥ 2842.54
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¥ 3319.60
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¥ 2307.00
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