- 商品介绍
- 规格参数
- 包装参数
General description
Chemokine receptor CXCR1 also refers as type I IL-8 receptor or IL-8RA is a class A, rhodopsin-like G-protein-coupled receptor, expressed mainly in neutrophils but not in T or B lymphocytes . It has a crucial role in cellular signal transduction and targeted as drug receptors. Monoclonal anti-CXCR-1 (IL-8 RA) antibody can be used to neutralize the bioactivity facilitated by human cell surface CXCR-1. Mouse anti-CXCR-1 (IL-8 RA) antibody reacts specifically with CXCR-1 transfected cells but not with the parent cell line. The product has also shown no cross-reactivity with human CXCR-2.
Immunogen
human CXCR1 transfected NSO mouse myeloma cells.
Application
Monoclonal anti-CXCR-1 (IL-8 RA) antibody can be used in flow cytometry for detecting CXCR-1 present on human blood cells. It can also be used in immunohistochemistry (25 μg/mL) using frozen human tissue sections (spleen).
Biochem/physiol Actions
The antiboody, in the presence of anti-CXCR2 (Sigma Product No. C6348), will neutralize human cell surface CXCR-1 mediated-myloperoxidase release from human granulocytes induced by IL-8. The antibody reacts with human CXCR1 transfectant cells and not the parent cell line. The antibody shows no cross-reactivity with CXCR2.
Physical form
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose.
Preparation Note
Purified using protein G.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
| biological source | mouse |
| Quality Segment | 100 |
| conjugate | unconjugated |
| antibody form | purified immunoglobulin |
| antibody product type | primary antibodies |
| clone | 42705.111, monoclonal |
| form | lyophilized powder |
| species reactivity | human |
| technique(s) | flow cytometry: 10 μg/mL using using human blood cells (10 μL diluted antibody/105-106 cells),immunohistochemistry (frozen sections): 25 μg/mL using human tissue (speen),neutralization: suitable |
| isotype | IgG2a |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| Gene Information | human ... IL8RA(3577) mouse ... Il8ra(227288) |
| 长度(mm) | |
| 宽度(mm) | |
| 高度(mm) | |
| 重量(kg) |
-
询价
-
询价
-
询价
-
¥ 4164.19
-
询价
-
¥ 1596.77
-
¥ 1779.22
-
¥ 2068.25
-
询价
-
询价
-
询价
-
¥ 8135.09
-
询价
-
¥ 4968.78
-
¥ 14407.09
-
¥ 745.60
-
¥ 4020.77
-
¥ 1476.40
-
¥ 2452.91
-
¥ 10685.48
微信小程序
7X24小时在线咨询