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- 规格参数
- 包装参数
General description
Rab10, a small monomeric Ras-related GTP-binding protein, is a member of the rat sarcoma (RAS) family. RAB10 gene has GTP and GDP binding domains. RAB10 gene is located on human chromosome 2p23.3.
Immunogen
Purified recombinant fragment of human Rab10 expressed in E.coli.
Mouse monoclonal antibody raised against Rab10
Application
Monoclonal Anti-RAB10 antibody produced in mouse has been used in western blotting (1:1000) and immunocytochemistry (1:1000).
Biochem/physiol Actions
RAB10 is involved in intracellular vesicle trafficking. It is important for insulin-stimulated glucose transporter type 4 (GLUT4) translocation in adipocytes, the secretion of the basement membrane, and endoplasmic reticulum development and maintenance (ER). It controls toll-like receptor 4 (TLR4) trafficking, which is crucial for innate immune responses. Rab10 gene knockdown reduces the production of Aβ and higher expression of Rab10 enhances amyloid β protein (Aβ) production in cultured neuroblastoma cells. Phosphorylation of Rab10 could be the cause of vesicle trafficking abnormalities that lead to neurodegeneration in Alzheimer′s disease. Overexpression of RAB10 is observed in hepatocellular carcinoma (HCC).
Physical form
Ascitic fluid containing 0.03% sodium azide.
Other Notes
2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
| biological source | mouse |
| Quality Segment | 100 |
| conjugate | unconjugated |
| antibody form | ascites fluid |
| antibody product type | primary antibodies |
| clone | 4E2, monoclonal |
| mol wt | 22.5 kDa |
| species reactivity | mouse, human |
| technique(s) | direct ELISA: 1:10,000,indirect immunofluorescence: 1:200-1:1,000,western blot: 1:500-1:2,000 |
| isotype | IgG1 |
| NCBI accession no. | NM_016131 |
| UniProt accession no. | P61026 |
| shipped in | wet ice |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| Gene Information | human ... Rab10(10890) |
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