- 商品介绍
- 规格参数
- 包装参数
General description
Calmodulin 3 (CALM3) encodes calmodulin (CaM) protein 3 which is expressed five folds more than CALM1 and CALM2. CALM3 promoter has high GC content and no TATA box like that of housekeeping gene. CALM3 contains several pro-alpha1 (AP1) and pro-alpha2 (AP2) consensus sites and several CAAT regions. CALM3 also has clusters of specificity protein 1 (SP1) transcription factor. In human chromosome, the gene is localized on 19q13.32.
Immunogen
Peptide sequence around phosphorylation site of threonine79/serine81(K-D-T(p)-D-S(p)-E-E) derived from Human Calmodulin .
Biochem/physiol Actions
Calmodulin (CaM) encoded by Calmodulin 3 (CALM3) senses Ca2+ and binds to free signal-transducing protein that regulates Cav1.2 L-type calcium channel and deactivates Cav1.2 when CaM binds to free Ca2+. A sporadic mutation in CALM3 might be the cause for long QT syndrome, a disorder of ventricular myocardial repolarization, characterized by prolonged heart rate. CALM3 expression is higher in teratoma cells. CALM3 is a potential biomarker to dysregulate the melanoma cancer genes. Polymorphism in CALM3 is a potential modifier gene for familial hypertrophic cardiomyopathy.
The antibody detects endogenous level of Calmodulin only when phosphorylated at threonine 79/serine 81.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
| biological source | rabbit |
| Quality Segment | 100 |
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone | polyclonal |
| form | buffered aqueous solution |
| mol wt | 17 kDa |
| species reactivity | rat, mouse, human |
| concentration | 1.0 mg/mL |
| technique(s) | western blot: 1:500-1:1000 (Cell Lysate) |
| isotype | IgG |
| accession no. | NP_005175.2 |
| UniProt accession no. | P0DP25 |
| shipped in | wet ice |
| storage temp. | −20°C |
| target post-translational modification | phosphorylation (pThr79) |
| Gene Information | human ... CALM3(808) |
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