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- 规格参数
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Biochem/physiol Actions
PKUMDL-WQ-2201 is a potent and selective non-NAD+-competing allosteric inhibitor of phosphoglycerate dehydrogenase (PHGDH) that selectively inhibits serine synthesis in cancer cells. PKUMDL-WQ-2201 binds to allosteric site II, which is located in the substrate-binding domain. PKUMDL-WQ-2201 inhibits tumor growth of MDA-MB-468 xenografts in mice.
Potent and selective non-NAD+-competing allosteric inhibitor of phosphoglycerate dehydrogenase (PHGDH)
| assay | ≥98% (HPLC) |
| form | powder |
| color | white to brown |
| solubility | DMSO: 15 mg/mL, clear |
| storage temp. | 2-8°C |
| SMILES string | O=C(C(C=CC(C1=CC=C(C=NNC(NCC)=S)O1)=C2)=C2Cl)O |
| InChI | 1S/C15H14ClN3O3S/c1-2-17-15(23)19-18-8-10-4-6-13(22-10)9-3-5-11(14(20)21)12(16)7-9/h3-8H,2H2,1H3,(H,20,21)(H2,17,19,23) |
| InChI key | XPACBFAEZIPDRT-UHFFFAOYSA-N |
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¥ 625.35
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¥ 805.47
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¥ 3895.14
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¥ 1029.59
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¥ 656.88
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¥ 1540.85
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¥ 2396.11
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