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Biochem/physiol Actions
GAT211 is a positive allosteric modulator (PAM) of cannabinoid CB1 receptor signaling.
GAT211 is a positive allosteric modulator (PAM) of cannabinoid CB1 receptor signaling. GAT211 was found to amplify the therapeutic effect of endocannabinoids without the negative side effects of psychoactivity or tolerance. GAT211 caused a CB1-dependent suppression of paclitaxel-induced mechanical and cold allodynia with no sign of tolerance over 19 days of administration.
| Quality Segment | 100 |
| assay | ≥98% (HPLC) |
| form | powder |
| color | white to beige |
| solubility | DMSO: 10 mg/mL, clear |
| web metadata keyword.default | 3-(2-Nitro-1-phenylethyl)-2-phenyl-1H-indole research grade,3-(2-Nitro-1-phenylethyl)-2-phenyl-1H-indole,CAS 102704-40-5 GAT211 neuroscience research,GAT211 cannabinoid receptor modulator,GAT211 cannabinoid signaling PAM,GAT211 for cannabinoid signaling studies,GAT211 for lab research,GAT211 high purity allosteric modulator,GAT211 neuroscience applications positive modulator,GAT211 positive allosteric modulator CB1 receptor,Sigma-Aldrich GAT211 positive allosteric modulator,high purity GAT211 for neuroscience applications,order GAT211 for pharmacological studies |
| storage temp. | 2-8°C |
| SMILES string | O=[N+]([O-])CC(C1=CC=CC=C1)C2=C(C3=CC=CC=C3)NC4=CC=CC=C42 |
| InChI | 1S/C22H18N2O2/c25-24(26)15-19(16-9-3-1-4-10-16)21-18-13-7-8-14-20(18)23-22(21)17-11-5-2-6-12-17/h1-14,19,23H,15H2 |
| InChI key | OHZDCJJHWPHZJD-UHFFFAOYSA-N |
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