ABL2 (38-end), active, His tagged human,10UG,A0733-10UG,Sigma

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订货号 0BT9411
品牌型号 Sigma A0733-10UG
货期 询货期
最小订货量 1件
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产品介绍 Product Description

Biochem/physiol Actions

ABL2 (or ARG) is a nonreceptor cytoplasmic tyrosine kinase which is closely related to but distinct from ABL1. The similarity of ABL1 and ABL2 includes the tyrosine kinase domains and extends amino-terminal to include the SH2 and SH3 domains. ABL2 is involved in translocation with the ETV6 gene in human leukemia and has an altered expression in several human carcinomas. Two isoforms of ABL2 with different N-termini (1A and 1B) have been identified. The C-terminal domain of ABL2 contains two F-actin-binding sequences that perform a number of actions related to cell morphology and motility by interacting with actin filaments.


Physical form

Supplied in 50mM NaPhosphate pH 7.0, 300 mM NaCl, 150 mM imidazole, 0.1mM PMSF, 0.2 mM DTT, 25% glycerol.
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Legal Information

PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany


技术参数 Specifications
recombinantexpressed in baculovirus infected Sf9 cells
Quality Segment200
product linePRECISIO® Kinase
assay≥70% (SDS-PAGE)
formbuffered aqueous glycerol solution
specific activity1035-1401 nmol/min·mg
mol wt ~132 kDa
UniProt accession no.P42684
shipped indry ice
storage temp.−70°C
Gene Informationhuman ... ABL2(27)
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