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Biochem/physiol Actions
AZD2066 is an orally bioavailable, brain penetrant, selective and potent negative allosteric modulator of the metabotropic glutamate receptor subtype 5 (mGlu5). AZD2066 exhibited satisfactory efficacy in patients suffering from neuropathic pain with mechanical hypersensitivity.
orally bioavailable, brain penetrant, selective and potent negative allosteric modulator of the metabotropic glutamate receptor subtype 5 (mGlu5)
| Quality Level | 100 |
| assay | ≥98% (HPLC) |
| form | powder |
| color | white to beige |
| solubility | DMSO: 2 mg/mL, clear |
| storage temp. | −20°C |
| SMILES string | Clc1cc(ccc1)c2[o]nc(c2)[C@H](Oc3[n](c(nn3)c4ccncc4)C)C |
| InChI | 1S/C19H16ClN5O2/c1-12(16-11-17(27-24-16)14-4-3-5-15(20)10-14)26-19-23-22-18(25(19)2)13-6-8-21-9-7-13/h3-12H,1-2H3/t12-/m1/s1 |
| InChI key | SXWHYTICXCLKDG-GFCCVEGCSA-N |
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¥ 1683.78
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¥ 1779.22
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¥ 9207.92
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¥ 1653.62
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