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Biochem/physiol Actions
Methazolamide has a plasma half-life of 14 hours in humans. Methazolamide has relatively good lipid solubility and low plasma protein binding ability. Thus, it diffuses into tissues and fluids much more readily than acetazolamide, another carbonic anhydrase inhibitor. Methazolamide has less side effects than acetazolamide.
Cell-permeable and potent carbonic anhydrase (CA) inhibitor
Methazolamide is a cell-permeable and potent carbonic anhydrase (CA) inhibitor that is used in the treatment of glaucoma. Methazolamide is an insulin sensitizer that reduces hepatic glucose generation in animal models.
Other Notes
Light sensitive
| Quality Level | 100 |
| assay | ≥98% (HPLC) |
| form | powder |
| storage condition | protect from light |
| color | white to beige |
| mp | 208 °C (dec.) (lit.) |
| solubility | DMSO: 20 mg/mL, clear |
| storage temp. | 2-8°C |
| SMILES string | CN1N=C(S\C1=N\C(C)=O)S(N)(=O)=O |
| InChI | 1S/C5H8N4O3S2/c1-3(10)7-4-9(2)8-5(13-4)14(6,11)12/h1-2H3,(H2,6,11,12)/b7-4+ |
| InChI key | FLOSMHQXBMRNHR-QPJJXVBHSA-N |
| Gene Information | human ... CA1(759), CA2(760), CA4(762), CA7(766) |
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