- 商品介绍
- 规格参数
- 包装参数
General description
Monoclonal Anti-EDEM3 (mouse IgG1 isotype) is derived from the hybridoma EDEM3-1 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a synthetic peptide corresponding to a fragment of human EDEM3 conjugated to KLH.
Three EDEM homologs, EDEM1, EDEM2 and EDEM3 have been identified, which are transcriptionally upregulated upon ER stress by the activated IRE1/Xbp-1 branch.
Application
Monoclonal Anti-EDEM3 antibody produced in mouse has been used in immunoblotting.
Biochem/physiol Actions
EDEM3 (ER degradation enhancer, mannosidase α-like 3), a soluble EDEM homolog, enhances glycoprotein endoplasmic reticulum-associated degradation (ERAD) and mannose trimming. EDEM3 accelerates ERAD of misfolded glycoproteins as well, but in ontrast to EDEM1, it greatly stimulates mannosidase trimming in vivo.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
| biological source | mouse |
| Quality Segment | 200 |
| conjugate | unconjugated |
| antibody form | purified immunoglobulin |
| antibody product type | primary antibodies |
| clone | EDEM3-1, monoclonal |
| form | buffered aqueous solution |
| mol wt | antigen ~120 kDa |
| species reactivity | rat, mouse, human |
| concentration | ~1.0 mg/mL |
| technique(s) | western blot: 1-2 μg/mL using whole extract of mouse 3T3 or rat NRK cells |
| UniProt accession no. | Q9BZQ6 |
| shipped in | dry ice |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| Gene Information | human ... EDEM3(80267) mouse ... Edem3(66967) rat ... Edem3(289085) |
| 长度(mm) | |
| 宽度(mm) | |
| 高度(mm) | |
| 重量(kg) |
-
询价
-
¥ 2013.69
-
询价
-
询价
-
询价
-
¥ 3275.78
-
询价
-
询价
-
询价
-
无菌，PETG 方形有刻度培养基瓶，带盖，聚对苯二酸乙二醇酯共聚物，天然高密度聚乙烯盖，500毫升容量，每箱40，40/箱，342020-0500，Nalgene，Thermofisher，赛默飞世尔¥ 3684.34
-
¥ 2151.46
-
¥ 3335.66
-
¥ 2617.87
-
¥ 1564.00
-
¥ 5014.59
-
¥ 3031.24
-
NNALGENE 180透明塑料管，透明，柔软，多用，经济，内径 x 外径x壁厚，1/4 x 1/2 x 1/8，英寸，每箱数量50，50/箱，8000-0080，Thermofisher，赛默飞世尔询价
-
¥ 2888.88
-
¥ 2754.43
-
询价
微信小程序
7X24小时在线咨询