R-(+)-DIOA,50MG,D129-50MG,Sigma

销售价: ¥ 10350.62 / 件
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订货号 0BT3203
品牌型号 Sigma D129-50MG
货期 询货期
最小订货量 1件
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  • 规格参数
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产品介绍 Product Description

Application

R-(+)-DIOA has been used as a potassium/chloride K+-Cl- transport inhibitor to study its effects on:

  • short circuit current (Isc) in rat semicircular canal duct (SCCD) epithelium
  • uptake of grepafloxacin by THP-1 monocytes
  • the uptake of moxifloxacin by THP-1 monocytes


Biochem/physiol Actions

[(dihydroindenyl)oxy]acetic acid (DIOA) acts as a potent inhibitor of potassium/chloride (K+–Cl) co-transporter. It does not exert its effects on bumetanimide-sensitive [Na+,K+,Cl-]-cotransport system.


技术参数 Specifications
Quality Level100
assay≥98% (HPLC)
formsolid
optical activity[α]27/D +18.1°, c = 0.7 in methanol(lit.)
color white
solubilityH2O: insoluble <0.11 mg/mL,DMSO: >20 mg/mL,0.1 M HCl: insoluble,0.1 M NaOH: soluble,ethanol: soluble
SMILES stringCCCC[C@]1(Cc2cc(OCC(O)=O)c(Cl)c(Cl)c2C1=O)C3CCCC3
InChI1S/C20H24Cl2O4/c1-2-3-8-20(13-6-4-5-7-13)10-12-9-14(26-11-15(23)24)17(21)18(22)16(12)19(20)25/h9,13H,2-8,10-11H2,1H3,(H,23,24)/t20-/m0/s1
InChI keyYAWWQIFONIPBKT-FQEVSTJZSA-N
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