Progranulin rat，10UG，SRP8017-10UG，Sigma

销售价： ¥ 2529.48 / 件

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订货号： 0BT3027

品牌型号： Sigma SRP8017-10UG

货期：询货期

最小订货量： 1件

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包装参数

产品介绍 Product Description

General description

Progranulin (PGRN) is a widely expressed pluripotent growth factor which plays a role in processes such as development, wound repair and inflammation by activating signaling cascades that control cell cycle progression and cell motility. Its function in the central nervous system is of interest, as mutations in the PGRN gene were found in cases of frontotemporal degeneration (FTLD). In addition, PGRN has also been linked to tumorigenesis. Progranulin is a biomarker for FTLD, other types of Alzheimer′s Disease (AD) and potentially for MCI (Mild Cognitive Impairment). Additionally, PGRN is described as a new ligand of TNF receptors and a potential therapeutic against inflammatory disease like arthritis.

Physical form

Lyophilized from 0.2 μm-filtered solution in PBS.

Preparation Note

Reconstitute with 100 μL deionized water.

Other Notes

Signal peptide and rat progranulin (aa 1-602) are fused at the C-terminus to a FLAG^®-tag.

Legal Information

FLAG is a registered trademark of Merck KGaA, Darmstadt, Germany

技术参数 Specifications

biological source	rat
recombinant	expressed in HEK 293 cells
tag	FLAG^® tagged
assay	>95% (SDS-PAGE)
form	lyophilized
mol wt	~65 kDa by SDS-PAGE
packaging	pkg of 10 μg
manufacturer/tradename	Sigma-Aldrich
storage condition	avoid repeated freeze/thaw cycles
impurities	<0.1 EU/μg endotoxin, tested
color	white
UniProt accession no.	P23785
shipped in	wet ice
storage temp.	−20°C
Gene Information	rat ... Grn(29143)

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