- 商品介绍
- 规格参数
- 包装参数
Biochem/physiol Actions
Natural analgesic that induces pain relieve though activation of atypical scavenger receptor for chemokines and opioid peptides ACKR3 (CXCR7).
Conolidine is a natural analgesic isolated from tropical flowering shrub Tabernaemontana divaricate, which exhibits potent analgesia in in vivo models of tonic and persistent pain. Conolidine induces pain relieve though activation of atypical scavenger receptor for chemokines and opioid peptides ACKR3 (CXCR7). It appears that conolidine inhibits scavenging functions of ACKR3 therefore increasing levels of endogenous opioid peptides.
| Quality Segment | 100 |
| assay | ≥98% (HPLC) |
| form | powder |
| color | white to beige |
| solubility | DMSO: >2 mg/mL, clear |
| storage temp. | -10 to -25°C |
| SMILES string | O=C(C1=C(C[N@](CC2)C/3)C4=C(C=CC=C4)N1)[C@@H]2C3=C(C)\[H] |
| InChI | 1S/C17H18N2O/c1-2-11-9-19-8-7-12(11)17(20)16-14(10-19)13-5-3-4-6-15(13)18-16/h2-6,12,18H,7-10H2,1H3/b11-2-/t12-/m0/s1 |
| InChI key | DBGBUYFOJXOYNY-RENATIMJSA-N |
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¥ 2528.88
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¥ 1596.77
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¥ 3109.49
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¥ 8135.09
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¥ 6330.00
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¥ 4404.38
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¥ 8137.12
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¥ 3476.87
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¥ 8072.66
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