Anti RB1 Antibody, clone 23GB2535, Rabbit Monoclonal，1004G，SAB6012221-100UL，Sigma 供应商、价格、厂家、报价、规格参数

产品介绍 Product Description

General description

The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma. [provided by RefSeq, Jul 2008]
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Immunogen

A synthesized peptide corresponding to a sequence within amino acids 701-928 of human Retinoblastoma [NP_000312.2].

Physical form

Solution in PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.

Other Notes

Gently mix before use. Optimal concentrations and conditions for each application should be determined by the user.

技术参数 Specifications

biological source	rabbit (Monoclonal)
Quality Segment	100
recombinant	expressed in HEK 293 cells
conjugate	unconjugated
antibody form	affinity isolated antibody
antibody product type	primary antibodies
clone	23GB2535, recombinant monoclonal
form	buffered aqueous glycerol solution
mol wt	106 kDa
species reactivity	human
packaging	vial of 1.5 mL
enhanced validation	recombinant expression Learn more about Antibody Enhanced Validation
sustainability	Greener Alternative Product
concentration	1.5 mg/ml
technique(s)	flow cytometry: 1:2000,immunofluorescence: 1:100-:1000,western blot: 1:1,000-1:5,000
isotype	IgG
Ensembl \| human accession no.	ENSG00000139687
NCBI accession no.	NP_000312.2
UniProt accession no.	P06400
greener alternative category	DfS-Developed
shipped in	wet ice
storage temp.	−20°C
target post-translational modification	unmodified
Gene Information	human ... RB1(5925)

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