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General description
This gene encodes a member of the receptor tyrosine kinase family of proteins. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that form a heterotetrameric receptor. Binding of insulin or other ligands to this receptor activates the insulin signaling pathway, which regulates glucose uptake and release, as well as the synthesis and storage of carbohydrates, lipids and protein. Mutations in this gene underlie the inherited severe insulin resistance syndromes including type A insulin resistance syndrome, Donohue syndrome and Rabson-Mendenhall syndrome. Alternative splicing results in multiple transcript variants.
Immunogen
A synthetic phosphorylated peptide around Y1361 of human INSR (NP_000199.2).
Physical form
PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Preparation Note
Store at -20℃. Avoid freeze / thaw cycles.
| biological source | rabbit |
| Quality Segment | 100 |
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone | polyclonal |
| form | buffered aqueous solution |
| mol wt | 155, 156 |
| species reactivity | human |
| concentration | 1.21 mg/ml |
| technique(s) | western blot: 1:500-1:2000 |
| UniProt accession no. | P06213 |
| shipped in | wet ice |
| storage temp. | −20°C |
| target post-translational modification | phosphorylation (pTyr1361) |
| Gene Information | human ... INSR(3643) |
| 长度(mm) | |
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| 重量(kg) |
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¥ 1596.77
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¥ 3152.47
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¥ 5167.58
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¥ 1568.60
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¥ 8137.12
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¥ 4020.77
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¥ 2288.54
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¥ 5990.26
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¥ 56581.65
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¥ 14985.93
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¥ 18741.69
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