- 商品介绍
- 规格参数
- 包装参数
General description
Sestrin 2 (SESN2), a highly conserved protein, is a member of a family of anti-aging proteins called the sestrins. Human SESN2 (hSESN2) contains three subdomains, such as SESN-A, SESN-B, and SESN-C. The SESN2 gene is mapped to human chromosome 1p35.3.
Application
Sestrin 2 human may be used to study its role on blood brain- barrier (BBB) stabilization after moderate and severe hypoxic- ischemic (HI) injuries in neonatal rats.
Biochem/physiol Actions
Sestrin 2 (SESN2) plays a vital role in modulating cellular stress response and oxidant defense. It plays a regulatory role in energy metabolism, cell fate, liver diseases, inflammation, and carcinogenesis. This novel anti-aging protein aids to maintain mitochondrial activities and enhance mitochondrial health. Since SESN2 is capable of protecting tissues from oxidative stress and mitochondrial dysfunction caused by ischemia or reperfusion (I/R), it may be a promising therapeutic target in hepatic regeneration.
| biological source | human |
| recombinant | expressed in baculovirus infected Sf9 cells |
| assay | ≥35% (SDS-PAGE) |
| form | aqueous solution |
| mol wt | 55 kDa |
| packaging | pkg of 50 μg |
| NCBI accession no. | NM_031459 |
| UniProt accession no. | P58004 |
| shipped in | dry ice |
| storage temp. | −70°C |
| Gene Information | human ... SESN2(83667) |
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¥ 1148.92
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¥ 4164.19
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¥ 1596.77
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¥ 8135.09
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¥ 3372.68
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¥ 5167.58
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¥ 3812.28
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¥ 4404.38
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¥ 8982.64
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¥ 2406.69
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¥ 5990.26
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¥ 75435.65
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¥ 8072.66
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