- 商品介绍
- 规格参数
- 包装参数
Biochem/physiol Actions
BTK (also known as Bruton tyrosine kinase) plays a crucial role in B-lymphocyte differentiation and activation. BTK interacts with SRC homology 3 domains of FYN, LYN and HCK that are activated upon stimulation of B- and T-cell receptors.Defects in the BTK gene cause Agammaglobulinemia, an X-linked immunodeficiency characterized by failure to produce mature B lymphocyte cells and associated with a failure of Ig heavy chain rearrangement. The unique role of BTK makes it a desirable target for potential anti-cancer, anti-inflammatory and anti-viral agents as well as other treatments.
Physical form
Supplied in 50mM NaPhosphate pH 7.0, 300 mM NaCl, 150 mM imidazole, 0.1mM PMSF, 0.2 mM DTT, 25% glycerol.
Legal Information
PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany
| biological source | human |
| Quality Segment | 100 |
| recombinant | expressed in baculovirus infected Sf9 cells |
| product line | PRECISIO® Kinase |
| assay | ≥70% (SDS-PAGE) |
| form | buffered aqueous glycerol solution |
| specific activity | 37-49 nmol/min·mg |
| mol wt | ~78 kDa |
| solubility | water: soluble |
| UniProt accession no. | Q06187 |
| application(s) | life science and biopharma |
| shipped in | dry ice |
| storage temp. | −70°C |
| Gene Information | human ... BTK(695) |
| 长度(mm) | |
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| 重量(kg) |
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