Anti-phospho-AR (pSer²¹³) antibody produced in rabbit，100UG，SAB4300098-100UG，Sigma 供应商、价格、厂家、报价、规格参数

产品介绍 Product Description

General description

The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: theN-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormoneactivated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins,translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This genecontains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in theN-terminal transactivation domain of its protein. Expansion of the polyglutamine tract causes spinal bulbar muscularatrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Twoalternatively spliced variants encoding distinct isoforms have been described.

Immunogen

Peptide sequence around phosphorylation site of serine 213 (E-A-S(p)-G-A), according to the protein AR.

Features and Benefits

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Physical form

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

技术参数 Specifications

biological source	rabbit
Quality Segment	100
conjugate	unconjugated
antibody form	affinity isolated antibody
antibody product type	primary antibodies
clone	polyclonal
form	buffered aqueous solution
mol wt	~110 kDa
species reactivity	human
concentration	1 mg/mL
technique(s)	indirect immunofluorescence: 1:100-1:200,western blot: 1:500-1:1000
isotype	IgG
immunogen sequence	(E-A-SP-G-A)
NCBI accession no.	NP_000035.2
UniProt accession no.	P10275
shipped in	wet ice
storage temp.	−20°C
target post-translational modification	phosphorylation (pSer213)
Gene Information	human ... AR(367)

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