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Anti-phospho-IGF1R (pTyr¹¹⁶⁵/pTyr¹¹⁶⁶) antibody produced in rabbit，100UG，SAB4300069-100UG，Sigma

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订货号： 0BS9785

品牌型号： Sigma SAB4300069-100UG

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最小订货量： 1件

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商品介绍
规格参数
包装参数

产品介绍 Product Description

General description

Insulin like growth factor 1 receptor (IGF1R) is encoded by the gene mapped to human chromosome 15q25- qter. The encoded protein is a transmembrane heterotetramer. It is structurally similar to insulin receptor.
This receptor binds insulin-like growth factor 1 (IGF1) with a high affinity and IGF2 with a lower affinity. It has a tyrosine-protein kinase activity, which is necessary for the activation of the IGF1-stimulated downstream signaling cascade. When present in a hybrid receptor with INSR, binds IGF1.

Immunogen

Peptide sequence around phosphorylation site of tyrosine 1165/tyrosine 1166 (T-D-Y(p)-Y(p)-R-K), according to the protein IGF1R.

Biochem/physiol Actions

Insulin like growth factor 1 receptor (IGF1R) on binding to its ligand, IGF2 regulates cell proliferation and growth. The encoded protein is also facilitates the normal embryonic and postnatal growth. It plays a crucial role in the embryonic growth. Mutations in IGF2 are associated with Silver–Russell syndrome and ring chromosome 15 syndrome. It is upregulated in ovarian cancer.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

技术参数 Specifications

biological source	rabbit
Quality Segment	100
conjugate	unconjugated
antibody form	affinity isolated antibody
antibody product type	primary antibodies
clone	polyclonal
form	buffered aqueous solution
mol wt	~200 kDa, ~95 kDa
species reactivity	rat, mouse, human
concentration	1 mg/mL
technique(s)	indirect immunofluorescence: 1:100-1:200,western blot: 1:500-1:1000
isotype	IgG
immunogen sequence	(T-D-YP-YP-R-K)
NCBI accession no.	NP_000866.1
UniProt accession no.	P08069
shipped in	wet ice
storage temp.	−20°C
target post-translational modification	phosphorylation (pTyr1165/pTyr1166)
Gene Information	human ... IGF1R(3480)

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