Anti-Progerin antibody, Mouse monoclonal，200UL，SAB4200272-200UL，Sigma

General description

Monoclonal Anti-Progerin (mouse IgG1 isotype) is derived from the hybridoma 13A4 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a synthetic peptide. A-type lamins, lamin A and lamin C are products of a single gene, LMNA, which are produced by alternative splicing. Prelamin A, the precursor of Lamin A, is farnesylated at its carboxy terminus after synthesis and the last 18 amino acids, which contain the farnesyl group, are removed by the metalloprotease Zmpste24, producing the mature Lamin A. The LMNA gene codes for A-type lamin, lamin A/C.

Application

Monoclonal Anti-Progerin antibody produced in mouse has been used in:

• immunoblotting
• immunoprecipitation
• immunofluorescence

Biochem/physiol Actions

Mutations in Lamin A have been linked to a variety of rare human diseases including muscular dystrophy, lipodystrophy, cardiomyopathy, neuropathy and progeroid syndromes (collectively termed laminopathies) and to premature aging (Hutchinson-Gilford progeria syndrome). Lamins A/C participate in maintaining nuclear integrity, modulation of gene expression, cell proliferation and apoptosis.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.