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General description
The gene LXR α (liver X receptor α) is a member of LXRs that belong to the nuclear receptor superfamily. The encoded protein is expressed predominantly in macrophages, liver, intestine, kidney, lung and adipose tissue. The gene is mapped to human chromosome 11p11.2. The protein contains a DNA-binding domain that requires the ligand-binding domain to heterodimerize with a retinoid X receptor partner for its DNA-binding activity.
The liver X receptors (LXRs) are encoded by two different genes, LXRα (NR1H3) and LXRβ (NR1H2). LXRα expression is restricted to macrophages and tissues involved in lipid metabolism.
Application
Anti-LXRα (N-terminal) antibody produced in rabbit has also been used for western blotting.
Anti-LXRα (N-terminal) antibody produced in rabbit has been used in immunofluorescence.
Biochem/physiol Actions
Liver X receptors (LXRs) heterodimerize with the retinoid X receptor (RXR) and bind to the LXR response element (LXRE). LXRs regulate cholesterol homeostasis by modulating the transcription of genes involved in its catabolism, storage, absorption and transport. Activated LXRs are also potent inhibitors of inflammatory responses in macrophages and reduce inflammation in vivo. LXR expression and activation with LXRs ligands have also been shown to modulate atherosclerotic lesions. LXRα/β-deficient mice show enhanced lipid-loaded foam cell accumulation. LXRs have been suggested to play an important role in Alzheimer′s disease (AD) pathogenesis.
The gene LXR α (liver X receptor α) encodes a protein that plays an important role in the control of cholesterol homeostasis. LXRs have been found to regulate inflammatory response in macrophages. They are also involved in the regulation of cell proliferation.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
| biological source | rabbit |
| Quality Segment | 200 |
| conjugate | unconjugated |
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone | polyclonal |
| form | buffered aqueous solution |
| mol wt | antigen ~50 kDa |
| species reactivity | human |
| enhanced validation | recombinant expression Learn more about Antibody Enhanced Validation |
| concentration | ~1.5 mg/mL |
| technique(s) | western blot: 1-2 μg/mL using HEK-293T cells expressing human LXRα |
| UniProt accession no. | Q13133 |
| shipped in | dry ice |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| Gene Information | human ... NR1H3(10062) mouse ... Nr1h3(22259) rat ... Nr1h3(58852) |
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