- 商品介绍
- 规格参数
- 包装参数
General description
Low density lipoprotein receptor-related protein 4 (LRP4) is expressed on the surface of the postsynaptic membranes. It acts as a receptor for agrin. The protein belongs to the low-density lipoprotein receptor-related proteins (LRPs) family. The LRP4 gene is localized on human chromosome 11p11.2.
Immunogen
Peptide with sequence CSNPSYRTSTQEVK , from the internal region of the protein sequence according to NP_002325.2.
Biochem/physiol Actions
LRP4 (Low density lipoprotein receptor-related protein 4) is a multifunctional protein which controls the extracellular cell signaling pathways including Wnt β-catenin signaling. It is highly essential for maintaining the bone mineral density. LRP4 binds to Dkk1 (dickkopf 1) and sclerostin to control the bone growth via Wnt and bone morphogenic protein (BMP) signaling pathways. Clinically, it is highly important for the development of osteoporosis. Mutation in the LRP4 gene causes an autosomal-recessive congenital disorder, Cenani-Lenz syndrome characterized with limb and kidney malformations.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form
Supplied at 0.5 mg/mL in Tris saline with 0.02% sodium azide and 0.5% bovine serum albumin.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
| biological source | goat |
| Quality Segment | 100 |
| conjugate | unconjugated |
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone | polyclonal |
| form | buffered aqueous solution |
| species reactivity | human |
| technique(s) | indirect ELISA: suitable,western blot: suitable |
| UniProt accession no. | O75096 |
| shipped in | dry ice |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| Gene Information | human ... LRP4(4038) |
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¥ 2528.88
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¥ 2290.21
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¥ 2814.26
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¥ 238.17
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¥ 6330.00
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¥ 4390.38
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¥ 3319.60
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¥ 1564.00
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