- 商品介绍
- 规格参数
- 包装参数
General description
The INS gene encodes for preproinsulin, which is enzymatically converted into insulin. Insulin is produced by the β cells in the Islets of Langerhans. Preproinsulin is converted to proinsulin in the endoplasmic reticulum and proinsulin is then proteolytically processed to form insulin in newly-forming insulin secretory granules. Insulin production is tightly regulated by specific DNA elements present within ~400 bp in the proximal region of the INS promoter.
Immunogen
Human insulin
Application
Anti-Insulin antibody, Mouse monoclonal has been used in immunohistochemistry.
Biochem/physiol Actions
Insulin is responsible for two types of actions- excitatory and inhibitory. In its excitatory role, it increases the uptake of glucose and lipid synthesis, and in its inhibitory role it inhibits glycogenolysis, gluconeogenesis, lipolysis, proteolysis and ketogenesis. Aberrant insulin secretion leads to various disorders such as diabetes, hyperglycemia or hypoglycemia. Mutant INS-gene Induced diabetes of youth (MIDY) syndrome is an autosomal dominant disorder caused by missense mutations, which lead to aberrant proinsulin folding. Impaired glucose tolerance (IGT) or non-insulin-dependent diabetes mellitus (NIDDM) is caused by resistance to insulin-stimulated glucose uptake.
Physical form
Solution in 0.01 M phosphaste buffered saline pH 7.4, containing 15 mM sodium azide.
Legal Information
ExtrAvidin is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
| biological source | mouse |
| Quality Level | 200 |
| antibody form | purified immunoglobulin |
| antibody product type | primary antibodies |
| clone | K36AC10, monoclonal |
| form | buffered aqueous solution |
| species reactivity | guinea pig, porcine, bovine (proinsulin), rat, monkey, sheep, dog, horse, human (insulin ), rabbit |
| technique(s) | immunoblotting: suitable,immunocytochemistry: suitable,immunohistochemistry: 10 μg/mL using heat-retrieved formalin-fixed, paraffin-embedded human pancreas sections and Biotin/ExtrAvidin®-Peroxidase staining system.,radioimmunoassay: suitable,immunofluorescence: 2.5-5 μg/mL using β -TC-6 Mouse Embryo Pancrease Insulinoma cells. |
| isotype | IgG1 |
| shipped in | dry ice |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| Gene Information | bovine ... Ins(280829) dog ... Ins(483665) guinea pig ... Ins(100379579) horse ... Ins(111776000) human ... INS(3630) pig ... Ins(397415) rabbit ... Ins(100009181) rhesus monkey ... Ins(704534) |
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