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Zoniporide hydrochloride hydrate，50MG，SML0076-50MG，Sigma

销售价： ¥ 12187.37 / 件

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订货号： 0BS4216

品牌型号： Sigma SML0076-50MG

货期：询货期

最小订货量： 1件

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产品介绍 Product Description

Application

Zoniporide hydrochloride hydrate has been used for the inhibition of sodium-hydrogen exchanger isoform 1 (NHE-1) in rat models. It has also been used in cytotoxicity assay and to study its effect on lymphocytic choriomeningitis virus multiplication.
Zoniporide hydrochloride hydrate may be used in Na⁺/H⁺-mediated cell signaling studies.

Biochem/physiol Actions

Potent and selective inhibitor of Na⁺/H⁺ exchanger isoform 1 (NHE-1)
Zoniporide is a potent and selective inhibitor of Na⁺/H⁺ exchanger isoform 1 (NHE-1). IC₅₀ = 59 nM at NHE-1, vs. 12,000 nM at NHE-2; Zoniporide inhibits NHE-1-dependent Na⁺ update with IC₅₀ of 14 nM.
Zoniporide, a selective inhibitor of sodium-hydrogen exchanger isoform 1 (NHE-1) has cardioprotective effects against myocardial injuries and ischemic insults. It inhibits the swelling human platelets and attenuates cardiac contractile dysfunction in rats. Zoniporide might have neurotoxic effects as it causes peripheral sensory axonopathy.

技术参数 Specifications

Quality Level	100
assay	≥98% (HPLC)
form	powder
storage condition	desiccated
color	white to tan
solubility	H₂O: 2 mg/mL, clear (warmed)
storage temp.	2-8°C
SMILES string	O.Cl.NC(=N)NC(=O)c1cnn(-c2cccc3ncccc23)c1C4CC4
InChI	1S/C17H16N6O.ClH.H2O/c18-17(19)22-16(24)12-9-21-23(15(12)10-6-7-10)14-5-1-4-13-11(14)3-2-8-20-13;;/h1-5,8-10H,6-7H2,(H4,18,19,22,24);1H;1H2
InChI key	UCIJUEGJEFJRMP-UHFFFAOYSA-N

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