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Biochem/physiol Actions
AEG 3482 is an imidazothiadiazole sulfonamide of 281 D with an anti-apoptotic property.
AEG3284 is a compound that binds to heat shock protein 90 (HSP90), leading to heat shock factor 1 (HSF1) dependent expression of HSP70, an endogenous inhibitor of c-Jun N-terminal kinase (JNK) activity. Treatment of PC12 cells with AEF3284 blocks JNK dependent apoptosis.
AEG3284 is an indirect inhibitor of JNK activity; HSP90 binder.
Features and Benefits
This compound is featured on the MAPKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
| Quality Segment | 100 |
| assay | ≥98% (HPLC) |
| form | powder |
| color | faintly yellow to dark yellow |
| solubility | DMSO: ≥15 mg/mL |
| storage temp. | 2-8°C |
| SMILES string | NS(=O)(=O)c1nn2cc(nc2s1)-c3ccccc3 |
| InChI | 1S/C10H8N4O2S2/c11-18(15,16)10-13-14-6-8(12-9(14)17-10)7-4-2-1-3-5-7/h1-6H,(H2,11,15,16) |
| InChI key | MQUYTXDAVCOCMX-UHFFFAOYSA-N |
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瓶顶过滤器-500ml容量,MF75TM系列，聚苯乙烯外壳，75mmSFCA滤膜，孔径0.2um,适合瓶颈尺寸45mm，12/箱，291-4520，Nalgene，Thermofisher，赛默飞世尔¥ 1142.57
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¥ 1604.79
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¥ 3254.85
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¥ 145427.01
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¥ 14985.93
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