- 商品介绍
- 规格参数
- 包装参数
General description
Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+-mediated signals. Many of the substrates contain a PxIxIT motif and/or a LxVP motif. In response to increased Ca(2+ levels, dephosphorylates and activates phosphatase SSH1 which results in cofilin dephosphorylation. In response to increased Ca(2+ levels following mitochondrial depolarization, dephosphorylates DNM1L inducing DNM1L translocation to the mitochondrion. Dephosphorylates heat shock protein HSPB1 (By similarity. Dephosphorylates and activates transcription factor NFATC1. In response to increased Ca(2+ levels, regulates NFAT-mediated transcription probably by dephosphorylating NFAT and promoting its nuclear translocation. Dephosphorylates and inactivates transcription factor ELK1. Dephosphorylates DARPP32. May dephosphorylate CRTC2 at ′Ser-171′ resulting in CRTC2 dissociation from 14-3-3 proteins. Dephosphorylates transcription factor TFEB at ′Ser-211′ following Coxsackievirus B3 infection, promoting nuclear translocation.
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 422-521 of human Calcineurin A (Q08209).
PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Application
WB
| biological source | rabbit |
| Quality Segment | 100 |
| conjugate | unconjugated |
| material | colorless |
| clone | 5I6H8, monoclonal |
| form | liquid |
| mol wt | 59 kDa |
| species reactivity | rat, human |
| concentration | 0.95 mg/mL |
| technique(s) | western blot: 1:500 - 1:2000 |
| color | colorless |
| isotype | IgG |
| immunogen sequence | TLKGLTPTGMLPSGVLSGGKQTLQSATVEAIEADEAIKGFSPQHKITSFEEAKGLDRINERMPPRRDAMPSDANLNSINKALTSETNGTDSNGSNSSNIQ |
| UniProt accession no. | Q08209 |
| shipped in | wet ice |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| Gene Information | human ... PPP3CA(5530) |
| 长度(mm) | |
| 宽度(mm) | |
| 高度(mm) | |
| 重量(kg) |
-
询价
-
¥ 1563.36
-
¥ 2013.69
-
¥ 1451.54
-
询价
-
询价
-
¥ 3152.47
-
询价
-
询价
-
¥ 1653.62
-
¥ 4897.21
-
¥ 15214.65
-
¥ 2666.57
-
¥ 2617.87
-
¥ 1301.36
-
¥ 4020.77
-
¥ 2911.61
-
¥ 165230.53
-
¥ 14985.93
-
询价
微信小程序
7X24小时在线咨询