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Biochem/physiol Actions
Cell-permeable covalent recruiter of CUL2 E3 ligase FEM1B that binds to C186 of FEM1B
EN106 is a cell-permeable covalent recruiter of CUL2 E3 ligase FEM1B that binds to C186 of FEM1B. EN106 disrupts FEM1B interactions with the FNIP1 degron and inhibits CUL2FEM1B-dependent ubiquitylation without detectable off-target effects. A modified EN106 bifunctional analog (PROTAC) recruits FEM1B and induces targeted BRD4 and BCR-ABL/c-ABL degradation.
| Quality Segment | 100 |
| assay | ≥98% (HPLC) |
| form | powder |
| color | white to beige |
| solubility | DMSO: 2 mg/mL, clear |
| storage temp. | 2-8°C |
| SMILES string | O=C(CCl)N(C1=CC2=C(OCCO2)C=C1)CCC#N |
| InChI key | GLDJSVHDOXCYPT-UHFFFAOYSA-N |
| 长度(mm) | |
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| 重量(kg) |
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