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General description
The protein encoded by this gene is an actin-binding protein that crosslinks actin filaments and links actin filaments to membrane glycoproteins. The encoded protein is involved in remodeling the cytoskeleton to effect changes in cell shape and migration. This protein interacts with integrins, transmembrane receptor complexes, and second messengers. Defects in this gene are a cause of several syndromes, including periventricular nodular heterotopias (PVNH1, PVNH4), otopalatodigital syndromes (OPD1, OPD2), frontometaphyseal dysplasia (FMD), Melnick-Needles syndrome (MNS), and X-linked congenital idiopathic intestinal pseudoobstruction (CIIPX). Two transcript variants encoding different isoforms have been found for this gene.
Immunogen
A synthetic phosphorylated peptide around S2152 of human FLNA (NP_001104026.1).
Physical form
PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Preparation Note
Store at -20℃. Avoid freeze / thaw cycles.
| biological source | rabbit |
| Quality Segment | 100 |
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone | polyclonal |
| form | buffered aqueous solution |
| mol wt | 280 |
| species reactivity | rat, mouse, human |
| concentration | 1.7 mg/ml |
| technique(s) | western blot: 1:500-1:2000 |
| UniProt accession no. | P21333 |
| shipped in | wet ice |
| storage temp. | −20°C |
| target post-translational modification | phosphorylation (pSer2152) |
| Gene Information | human ... FLNA(2316) |
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¥ 1596.77
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¥ 4039.86
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¥ 4173.75
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¥ 8293.41
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¥ 8520.40
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¥ 3896.11
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¥ 1351.48
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¥ 3476.87
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