- 商品介绍
- 规格参数
- 包装参数
Application
Interleukin-12 (IL-12) human has been used to study IL-12 mediated enhancement of IL-12Rβ2 (IL-12 receptor) expression.
Biochem/physiol Actions
Interleukin-12 (IL-12) was identified as a factor secreted by human Epstein-Barr (EBV)-transformed B cell lines. IL-12, or Natural Killer Cell Stimulatory Factor (NKSF), is a 75 kDa disulfide-linked heterodimer of a 35 kDa subunit and 40 kDa subunit. IL-12 is produced predominantly by monocytes and NK cells and induces T cells and NK cells to produce IFN-γ. Human IL-12 is not active on mouse cells, but murine IL-12 is active on both murine and human lymphocytes. The biological activity of recombinant human IL-12 was measured by its ability to stimulate the proliferation of PHA-activated human T lymphoblasts. IL-12 has anti-angiogenic properties.
Physical form
lyophilized from a 0.2 μm filtered solution of PBS
Analysis Note
The specific activity was determined by the dose-dependent release of IFN-γ from the human NK92 cell line in presence of 20 ng/mL rIL-2.
Legal Information
HumanKine is a registered trademark of Proteintech Group, Inc. and Humanzyme, Inc
| biological source | human |
| Quality Segment | 200 |
| recombinant | expressed in HEK 293 cells |
| assay | ≥95% (SDS-PAGE) |
| form | lyophilized |
| potency | ≤2 ng/mL EC50 |
| mol wt | dimer 57 kDa (glycosylated) |
| packaging | pkg of 10 μg |
| technique(s) | cell culture | mammalian: suitable |
| impurities | endotoxin, tested |
| storage temp. | −20°C |
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¥ 503.76
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¥ 805.47
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¥ 521.16
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¥ 746.52
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¥ 3683.17
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¥ 1958.88
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¥ 6085.86
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¥ 3593.05
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¥ 907.59
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¥ 1137.02
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